publications

2025

1. Neuroimaging

   

   Deep multimodal learning for domain-level cognitive decline prediction in Alzheimer\’disease

   Fernando Garcı́a-Gutiérrez, Jordi A Matias-Guiu, and José Ayala

   Frontiers in Artificial Intelligence, 2025

   Bib

   @article{garcia2025deep,
     title = {Deep multimodal learning for domain-level cognitive decline prediction in Alzheimer\' disease},
     author = {Garc{\'\i}a-Guti{\'e}rrez, Fernando and Matias-Guiu, Jordi A and Ayala, Jos{\'e}},
     journal = {Frontiers in Artificial Intelligence},
     volume = {8},
     pages = {1731062},
     year = {2025},
     publisher = {Frontiers},
     doi = {10.3389/frai.2025.1731062},
   }

2. Neuroimaging

   

   Data-driven prediction of regional brain metabolism using neuropsychological assessment in Alzheimerś disease and behavioral variant Frontotemporal dementia

   Josefa Dı́az-Álvarez, Fernando Garcı́a-Gutiérrez, Pedro Bueso-Inchausti, and 8 more authors

   Cortex, 2025

   Bib

   @article{diaz2025data,
     title = {Data-driven prediction of regional brain metabolism using neuropsychological assessment in Alzheimer\'s disease and behavioral variant Frontotemporal dementia},
     author = {D{\'\i}az-{\'A}lvarez, Josefa and Garc{\'\i}a-Guti{\'e}rrez, Fernando and Bueso-Inchausti, Pedro and Cabrera-Mart{\'\i}n, Mar{\'\i}a Nieves and Delgado-Alonso, Cristina and Delgado-Alvarez, Alfonso and Diez-Cirarda, Maria and Valls-Carbo, Adrian and Fern{\'a}ndez-Romero, Lucia and Valles-Salgado, Maria and others},
     journal = {Cortex},
     volume = {183},
     pages = {309--325},
     year = {2025},
     publisher = {Elsevier},
     doi = {10.1016/j.cortex.2024.11.022},
   }

3. Neuroimaging

   

   Genetic dissection of hippocampal sclerosis of ageing using magnetic resonance imaging surrogates

   Clàudia Olivé, Itziar Rojas, Linda Zhang, and 8 more authors

   medRxiv, 2025
4. Neuropsychology

   

   Exploring sex differences in Alzheimerś disease: a comprehensive analysis of a large patient cohort from a memory unit

   Maitee Rosende-Roca, Fernando Garcı́a-Gutiérrez, Yahveth Cantero-Fortiz, and 8 more authors

   Alzheimerś Research & Therapy, 2025

2024

1. Neuroimaging

   

   Predicting changes in brain metabolism and progression from mild cognitive impairment to dementia using multitask Deep Learning models and explainable AI

   Fernando Garcı́a-Gutiérrez, Laura Hernández-Lorenzo, Marı́a Nieves Cabrera-Martı́n, and 4 more authors

   NeuroImage, 2024

   Bib

   @article{garcia2024predicting,
     title = {Predicting changes in brain metabolism and progression from mild cognitive impairment to dementia using multitask Deep Learning models and explainable AI},
     author = {Garc{\'\i}a-Guti{\'e}rrez, Fernando and Hern{\'a}ndez-Lorenzo, Laura and Cabrera-Mart{\'\i}n, Mar{\'\i}a Nieves and Matias-Guiu, Jordi A and Ayala, Jos{\'e} L and Initiative, Alzheimer\'s Disease Neuroimaging and others},
     journal = {NeuroImage},
     volume = {297},
     pages = {120695},
     year = {2024},
     publisher = {Elsevier},
     doi = {10.1016/j.neuroimage.2024.120695},
   }

2. Genetics

   

   Genetic-based patient stratification in Alzheimerś disease

   Laura Hernández-Lorenzo, Fernando Garcı́a-Gutiérrez, Ana Solbas-Casajús, and 3 more authors

   Scientific Reports, 2024

   Bib

   @article{hernandez2024genetic,
     title = {Genetic-based patient stratification in Alzheimer\'s disease},
     author = {Hern{\'a}ndez-Lorenzo, Laura and Garc{\'\i}a-Guti{\'e}rrez, Fernando and Solbas-Casaj{\'u}s, Ana and Corrochano, Silvia and Mat{\'\i}as-Guiu, Jordi A and Ayala, Jose L},
     journal = {Scientific Reports},
     volume = {14},
     number = {1},
     pages = {9970},
     year = {2024},
     publisher = {Nature Publishing Group UK London},
     doi = {10.1038/s41598-024-60707-1},
   }

3. Speech

   

   Unveiling the sound of the cognitive status: Machine Learning-based speech analysis in the Alzheimerś disease spectrum

   Fernando Garcı́a-Gutiérrez, Montserrat Alegret, Marta Marquié, and 8 more authors

   Alzheimerś Research & Therapy, 2024

   Bib

   @article{garcia2024unveiling,
     title = {Unveiling the sound of the cognitive status: Machine Learning-based speech analysis in the Alzheimer\'s disease spectrum},
     author = {Garc{\'\i}a-Guti{\'e}rrez, Fernando and Alegret, Montserrat and Marqui{\'e}, Marta and Mu{\~n}oz, Nathalia and Ortega, Gemma and Cano, Amanda and De Rojas, Itziar and Garc{\'\i}a-Gonz{\'a}lez, Pablo and Oliv{\'e}, Cl{\`a}udia and Puerta, Raquel and others},
     journal = {Alzheimer\'s Research \& Therapy},
     volume = {16},
     number = {1},
     pages = {26},
     year = {2024},
     publisher = {Springer},
     doi = {10.1186/s13195-024-01394-y},
   }

4. Neuropsychology

   

   FACEmemory\textregistered, an innovative online platform for episodic memory pre-screening: findings from the first 3,000 participants

   Montserrat Alegret, Fernando Garcı́a-Gutiérrez, Nathalia Muñoz, and 8 more authors

   Journal of Alzheimerś Disease, 2024

2023

1. Speech

   

   Harnessing acoustic speech parameters to decipher amyloid status in individuals with mild cognitive impairment

   Fernando Garcı́a-Gutiérrez, Marta Marquié, Nathalia Muñoz, and 8 more authors

   Frontiers in Neuroscience, 2023

   Bib

   @article{garcia2023harnessing,
     title = {Harnessing acoustic speech parameters to decipher amyloid status in individuals with mild cognitive impairment},
     author = {Garc{\'\i}a-Guti{\'e}rrez, Fernando and Marqui{\'e}, Marta and Mu{\~n}oz, Nathalia and Alegret, Montserrat and Cano, Amanda and de Rojas, Itziar and Garc{\'\i}a-Gonz{\'a}lez, Pablo and Oliv{\'e}, Cl{\`a}udia and Puerta, Raquel and Orellana, Adelina and others},
     journal = {Frontiers in Neuroscience},
     volume = {17},
     pages = {1221401},
     year = {2023},
     publisher = {Frontiers Media SA},
     doi = {10.3389/fnins.2023.1221401},
   }

2. Neuropsychology

   

   The synergic effect of AT (N) profiles and depression on the risk of conversion to dementia in patients with mild cognitive impairment

   Marta Marquié, Fernando Garcı́a-Gutiérrez, Adelina Orellana, and 8 more authors

   International Journal of Molecular Sciences, 2023

   Bib

   @article{marquie2023synergic,
     title = {The synergic effect of AT (N) profiles and depression on the risk of conversion to dementia in patients with mild cognitive impairment},
     author = {Marqui{\'e}, Marta and Garc{\'\i}a-Guti{\'e}rrez, Fernando and Orellana, Adelina and Montrreal, Laura and de Rojas, Itziar and Garc{\'\i}a-Gonz{\'a}lez, Pablo and Puerta, Raquel and Oliv{\'e}, Cl{\`a}udia and Cano, Amanda and Hern{\'a}ndez, Isabel and others},
     journal = {International Journal of Molecular Sciences},
     volume = {24},
     number = {2},
     pages = {1371},
     year = {2023},
     publisher = {MDPI},
   }

2022

1. Neuropsychology

   

   Diagnosis of Alzheimerś disease and behavioural variant frontotemporal dementia with machine learning-aided neuropsychological assessment using feature engineering and genetic algorithms

   Fernando Garcia-Gutierrez, Alfonso Delgado-Alvarez, Cristina Delgado-Alonso, and 8 more authors

   International journal of geriatric psychiatry, 2022

   Bib

   @article{garcia2022diagnosis,
     title = {Diagnosis of Alzheimer\'s disease and behavioural variant frontotemporal dementia with machine learning-aided neuropsychological assessment using feature engineering and genetic algorithms},
     author = {Garcia-Gutierrez, Fernando and Delgado-Alvarez, Alfonso and Delgado-Alonso, Cristina and D{\'\i}az-{\'A}lvarez, Josefa and Pytel, Vanesa and Valles-Salgado, Maria and Gil, Mar{\'\i}a Jose and Hern{\'a}ndez-Lorenzo, Laura and Mat{\'\i}as-Guiu, Jorge and Ayala, Jos{\'e} L and others},
     journal = {International journal of geriatric psychiatry},
     volume = {37},
     number = {2},
     year = {2022},
     publisher = {Wiley Online Library},
   }

2. Neuropsychology

   

   GA-MADRID: Design and validation of a machine learning tool for the diagnosis of Alzheimerś disease and frontotemporal dementia using genetic algorithms

   Fernando Garcı́a-Gutierrez, Josefa Dı́az-Álvarez, Jordi A Matias-Guiu, and 4 more authors

   Medical & Biological Engineering & Computing, 2022

   Bib

   @article{garcia2022ga,
     title = {GA-MADRID: Design and validation of a machine learning tool for the diagnosis of Alzheimer\'s disease and frontotemporal dementia using genetic algorithms},
     author = {Garc{\'\i}a-Gutierrez, Fernando and D{\'\i}az-{\'A}lvarez, Josefa and Matias-Guiu, Jordi A and Pytel, Vanesa and Mat{\'\i}as-Guiu, Jorge and Cabrera-Mart{\'\i}n, Mar{\'\i}a Nieves and Ayala, Jos{\'e} L},
     journal = {Medical \& Biological Engineering \& Computing},
     volume = {60},
     number = {9},
     pages = {2737--2756},
     year = {2022},
     publisher = {Springer},
   }